Abstract
P084 To investigate whether familial aggregation of HTLV-I seropositivity could be explained in part by genetic factors, we conducted a large genetic epidemiology survey in an endemic population of French Guiana. All families of two Noir-Marron villages were included representing 94 pedigrees with 1567 subjects (730 females, 837 males) of whom 151 (9,6%) were HTLV-I positive. The familial segregation analysis was performed with regressive logistic models which are testing for the presence of a major gene taking into account simultaneously covariates influencing HTLV-I infection (e.g. age and gender) and other sources of familial dependencies (e.g. due to virus transmission routes). Results are consistent with the presence of a dominant major gene predisposing to HTLV-I infection in addition to the expected familial correlations (mother-offspring, spouse-spouse) due to the transmission routes of the virus. Under this genetic model, about 2% of the population is predicted to be highly predisposed to HTLV-I infection, and seropositive children <15 years are genetic cases whereas most HTLV-I seropositive adults are sporadic cases. Linkage and association studies with genetic markers are ongoing to confirm and identify these genetic factors.
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