Abstract
Genetic predisposition to cancer - an introduction from families to chromosomes - genetic linkage and other methods of finding cancer-predisposing genes how to isolate cancer-predisposing genes retinoblastoma - the paradigm for a genetically inherited cancer syndrome neurofibromatosis - types I and II multiple endocrine neoplasia - types I and II Wilms' tumor and other genetic causes of renal cancer the Li-Fraumeni syndrome and cancers arising from germline p53 mutations ataxia telangiectasia and radiation sensitivity Fanconi's anemia Gorlin's syndrome xeroderma pigmentosum and related syndrome genetics and the common cancers familial breast cancer the breast/ovarian cancer syndrome and BrCA1 screening for breast cancer in high-risk populations. The management of women with a high risk of breast cancer: (1) prophylactic tamoxifen (2) the contraversy of prophylactic mastectomy. familial prostrate cancer and its management psychological effects of the high-risk breast cancer the genetics of familial colon cancer familial melanoma and its management the organization of a familial cancer clinic screening for known cancer-predisposition genes the ethics of testing for cancer predisposition genes.
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