Abstract
P-275 Background: Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes may predict lead biomarkers in women and their children. Objective: Examine the association between HFE (hemochromatosis) and TF (transferrin) variants and body lead burden, comparing infants with their mothers. Methods: Blood and bone lead were obtained from 602 mothers and 424 infants. Mothers and infants were genotyped for H63D HFE and P570S TF variants. Maternal blood samples were collected at delivery, and 1, 3, 5 and 7 months post-partum. Maternal tibia lead was measured at 1 month post-partum. Children's blood lead was measured at delivery, and 18 and 24 months of age. Analyses compared H63D or P570S carriers with wildtype subjects in regressions conducted separately for mothers and infants. Results: 94% of subjects were successfully genotyped, 15% carried H63D and 21% carried P570S. In bivariate analysis, maternal blood lead at delivery did not vary by H63D genotype (wildtype mean[SD]=8.6[3.9] μg/dL, carrier mean[SD]=8.3[4.8] μg/dL, p=0.5). Maternal tibia lead was lower for carriers of H63D (wildtype mean[SD]=10.1[9.8] μg/gm bone, carrier mean[SD]=7.9[10.2] μg/gm bone, p=0.05). In multivariate regression, H63D was predictive of lower maternal tibia lead (β =−2.3, p=0.04), but not maternal blood lead at delivery (β =−0.50, p=0.3). Among children, H63D was associated with higher blood lead at 18 and 24 months of age (wildtype mean[SD] at 18 & 24 months=8.0[4.3] & 7.9[4.4] μg/dL respectively, carrier mean[SD] at 18 & 24 months=9.6[5.3] & 9.9[8.2] μg/dL respectively, p=0.03 and 0.02 respectively). P570S was marginally predictive of higher maternal blood lead at delivery (β =0.80, p=0.07), but not maternal tibia lead (β =−1.0, p=0.32). In GEE regression analysis, using repeated measures of maternal blood lead, P570S was associated with higher maternal blood lead (β =0.50, p=0.04). P570S did not predict children's blood lead. Conclusions: H63D variant is associated with lower bone lead in mothers, but higher blood lead among their children. There were no differences in umbilical cord lead by HFE genotype. The results for mothers are similar to previous reports of HFE genotype on bone and blood lead in elderly men. The results for children suggest that the HFE gene effect is modified by age.
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