Genetic predictors of arterial hypertension in young patients with metabolic syndrome

Abstract

The paper presents the results of studying the polymorphism of the genes rs1799752 of the ACE gene, αIIbβ3 integrin, rs1378942 of the CSK gene in the development of arterial hypertension in young patients with metabolic syndrome. Arterial hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. The occurrence of mutant alleles of the studied genes among the examined patients is quite high: thus, the carriage of the homozygous DD variant is 21.6%, and the carriage of the mutant D allele of the ACE gene is 47.4%. A high risk of developing hypertension in patients with MS was detected in carriers of the T rs1378942 CSK allele - 54.8%, which was most often observed in a combination of polymorphic loci of the ACE and CSK genes (p = 0.0053).