Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China

Zumurelaiti Ainiwaer,Sulaiya Husaiyin,Jing Liu,Lili Han,Reyilanmu Maisaidi,Jing Lu,Mayinuer Niyazi

doi:10.1186/s12881-020-01144-5

Zumurelaiti Ainiwaer, Sulaiya Husaiyin + Show 5 more

Open Access

https://doi.org/10.1186/s12881-020-01144-5

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Abstract

BackgroundPGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, there is currently no report investigating the relationship of PGF and TNFAIP2 gene polymorphisms to CC risk.MethodsWe conducted a case-control study of 342 CC patients and 498 cancer-free controls in a Chinese Uygur female population. Three SNPs (PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were selected and genotyped to assess the possible association of PGF and TNFAIP2 polymorphisms with CC susceptibility. Logistic regression analysis adjusted by age was used.ResultsPGF rs2268615 (OR = 1.39, 95% CI = 1.04–1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07–1.95, p = 0.018) polymorphisms were associated with the increased risk of CC. Moreover, T allele of PGF rs8019391 was highly represented in patients with stage III–IV compared with stage I-II (OR = 2.17, p = 4.58 × 10− 4). MDR analysis revealed a positive interaction between the SNPs.ConclusionOur data indicated that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms might be risk factors for CC susceptibility, which contributed to the increased risk of CC.Trial registrationNot applicable.

Highlights

Placental growth factor (PGF) and TNF alpha induced protein 2 (TNFAIP2) are important angiogenic factors, which were abnormal expression in cervical cancer (CC)
The minor allele frequency (MAF) distribution of PGF rs2268615-A allele and TNFAIP2 rs710100-A allele were higher in the case group, which increased the risk of CC
The results of multiple genetic model adjusted by age revealed PGF rs2268615 and TNFAIP2 rs710100 conferred to the increased CC risk (Table 2)

Summary

Introduction

PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). There is currently no report investigating the relationship of PGF and TNFAIP2 gene polymorphisms to CC risk. Cervical cancer (CC) is the fourth most common cancer, with an estimated 570,000 cases and 311, 000 deaths in 2018 [1]. Cervical cancer is the most common cancer of female genital system in China and the incidence of CC tends to be younger [2]. PGF has been reported as a potent stimulator in cancer invasion by activating angiogenesis [6]. TNFAIP2 (TNF alpha induced protein 2) is a primary response gene of TNFα, and the expression of TNFAIP2 is regulated by various transcription factors and signaling pathways, including NF-κB, KLF5 and retinoic acid

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