Genetic polymorphisms of IL-10, IL-18 and IL12B are associated with risk of non-small cell lung cancer in a Chinese Han population

Abstract

PurposeIL-10, IL-18 and IL-12 are reported to participate in the inflammation process. The potential influences of IL-10, IL-18 and IL-12 polymorphisms on non-small cell lung cancer (NSCLC) risk were explored in this study. MethodsSix candidate SNPs from 500 NSCLC patients and 500 controls were genotyped. The correlation between the SNPs and NSCLC risk was evaluated by logistic regression analysis. ResultsComparisons of the allele and genotype frequencies showed that five SNPs were correlated with NSCLC risk. The minor allele ‘G’ of IL-18 rs5744256 and rs1834481 and IL-10 rs3021094 was correlated with a decreased risk of NSCLC (p < 0.05). In contrast, the minor allele ‘T’ of IL-18 rs5744224 and the minor allele ‘G’ of IL-12B rs3212227 were correlated with an increased risk of NSCLC (p < 0.05). By genetic model analysis, we found that rs5744256 and rs1834481 were associated with a decreased risk of NSCLC under dominant and log-additive models (p < 0.05). Rs3021094 was correlated with a decreased risk of NSCLC under all three models (p < 0.05). In contrast, rs5744224 was associated with an increased risk of NSCLC under the recessive model (p = 0.005), and rs3212227 was associated with an increased risk of NSCLC under all three models (p < 0.05). Finally, the GGA haplotype of rs5744256, rs1834481 and rs5744224 and the GT haplotype of rs3021094 and rs3790622 were associated with a decreased risk of NSCLC (p < 0.05). ConclusionOur results provided new candidate SNPs for the prediction and prevention of NSCLC.