Abstract
Background: Tuberculosis is an important mycobacterial infection. This problem is still the present public health problem in several countries around the world. The genetic underlying factor is usually mentioned for the effect on the natural history of tuberculosis infection. Methods: Here, the authors perform a standard assessment on the molecular change due to TLR2 gene Arg753Gln and Arg677Trp polymorphisms and further study on the effect on the corresponding phenotypic expression changes. Results: The molecular weight changes comparing to naive molecule in cases of Arg753Gln and Arg677Trp polymorphisms are equal to –16.1% and +17.2%, respectively. Conclusion: According to the molecular structure analysis, Arg753Gln has a relationship with active tuberculosis whereas Arg677Trp polymorphism is not.
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