Abstract
Background The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR = 1.32, 95%CI = 1.03‐1.71 for C vs. G; OR = 1.50, 95%CI = 1.03‐2.19 for CG vs. GG; and OR = 1.44, 95%CI = 1.05‐1.99 for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (OR = 2.07, 95%CI = 1.01‐4.25 for C vs. G; OR = 2.08, 95%CI = 1.17‐3.71 for CC vs. GG; and OR = 1.78, 95%CI = 1.00‐3.15 for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (OR = 0.82, 95%CI = 0.72‐0.95 for T vs. G). Conclusions rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.
Highlights
Head and neck cancer (HNC) is the sixth most common cancer [1], which includes oral cancer, nasopharyngeal carcinoma, pharyngeal cancer and laryngeal neoplasm
According to the inclusion and exclusion criteria, ten papers involving a total of 2484 controls and 2377 cases were enrolled in our analysis after selection [29, 31,32,33,34,35,36,37,38,39]
With respect to RAD51 G135C polymorphism, the random-effects model was performed under all genetic models because the statistical heterogeneity between articles was substantial
Summary
Head and neck cancer (HNC) is the sixth most common cancer [1], which includes oral cancer, nasopharyngeal carcinoma, pharyngeal cancer and laryngeal neoplasm. The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. A significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR = 1:32, 95%CI = 1:03‐1:71 for C vs G; OR = 1:50, 95%CI = 1:03‐2:19 for CG vs GG; and OR = 1:44, 95%CI = 1:05‐ 1:99 for CC+CG vs GG). Our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. Our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians
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