Genetic polymorphisms in interleukin-17A were associated with typhoid fever in Babylon City in Iraq

Abstract

A total of 50 clinical samples were taken from the blood of typhoid fever patients who visited Al-Hillah Surgical Teaching Hospital and private laboratories in the AL-Hillah/Babylon region between February and August 2021. This research included 50 people who looked to be healthy and disease-free. Genotypes and allele frequency for rs1974226 showed individuals with two T alleles (homozygous for the TT) were significantly represented among the patients with typhoid fever: 14 (28%), P-value = 0.0061, as compared with healthy control subjects, 6 (12%), and had an increased risk of developing typhoid fever infection. The IL-17A (C) allele was less frequent among patients (62%, n =62) than control, and the (T) allele was more frequent among patients than control (38%, n =38). Genotypes and allele frequency for rs1974226 showed individuals with genotype TT were significantly represented among the patients with typhoid fever: 14 (28%), P-value = 0.0061, as compared with healthy control subjects, 6 (12%), and had an increased risk of developing typhoid fever infection. The data has been further examined for each genotype correlated with typhoid fever under different inheritance models.