Abstract
Recently, the functional polymorphisms in Cyclin D1 (CCND1) have been shown the potential influence to risk of renal cell cancer (RCC). Therefore, the present study was performed to investigate whether these polymorphisms could influence the susceptibility of RCC. Four potentially functional polymorphisms in CCND1 (rs1944129, rs7177, rs9344 and rs678653) were genotyped in this hospital-based case-control study, comprising of 1,488 RCC patients and 1,677 cancer-free controls in a Chinese population by the TaqMan assay. The logistic regression was used to assess the associations between CCND1 polymorphisms and the risk of RCC. We found the genotype and allele frequency distribution of rs1944129 and rs7177 were significantly associated with risk of RCC (P = 0.015 and P = 0.018, respectively). The analysis of combined risk alleles revealed that patients with 2-4 risk alleles showed an elevated risk of RCC compared to those with 0-1 risk alleles (OR = 1.35, 95% CI = 1.15 - 1.58, P < 0.001). Furthermore, compared with the genotypes containing G allele (AG and GG), the patients carrying the AA genotype in CCND1 rs1944129 polymorphism had a significantly greater prevalence of high clinical stage disease (OR = 0.56, 95% CI = 0.33 - 0.94, P = 0.029). These results suggested that these CCND1 polymorphisms rs1944129 and rs7177 might contribute to the susceptibility of RCC in the Chinese population.
Highlights
As a complex-trait disease, renal cell cancer (RCC) is considered as one of the most common type of the kidney malignancy with a high prevalence in older men (>70 years of age) and is estimated to account for approximately 90% of all renal malignancies [1,2,3,4]
These results suggested that these cyclin D1 (CCND1) polymorphisms rs1944129 and rs7177 might contribute to the susceptibility of RCC in the Chinese population
We evaluated the associations between CCND1 polymorphisms and the susceptibility and clinicopathological development of RCC in a Chinese population
Summary
As a complex-trait disease, renal cell cancer (RCC) is considered as one of the most common type of the kidney malignancy with a high prevalence in older men (>70 years of age) and is estimated to account for approximately 90% of all renal malignancies [1,2,3,4]. The accurate etiology of RCC is not completely well-understood, its development is involved in a series of complex environmental and lifestyle factors, including obesity, ethnicity, age, tobacco smoking, alcohol consumption, diabetes, hypertension, occupational exposures to chemicals and family history [3, 5,6,7,8]. As a member of the D-type cyclin family, cyclin D1 (CCND1) was a proto-oncogene and a good biomarker for tumor progression, found to be deregulated in several cancers, including RCC [10]. The accumulating evidences discoveried that increased expression of CCND1 disrupted normal cell cycle process and possibly promoted the development of many malignant cancers, including RCC, which might be closely associated with metastases and the poor prognosis [15,16,17]
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