Abstract
PURPOSE: About one-third of women with asthma (A) have an increase in asthma symptoms during in menstrual period. Patients affected by premenstrual asthma (PA) in comparison to asthmatic women without premenstrual asthma (WPA), generally have more sever symptoms and more frequently hospitalization. Hormonal fluctuations and changes during the menstrual cycle may be responsible for PA occurring. GSTT1, GSTM1 genes take part in detoxification and excretion of xenobiotics from organism, and also in metabolism of prostaglandins, leukotreine and sexual hormones.
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