Abstract
Genetic variation of drug-metabolizing enzymes has been recognized as one of the major causes of the interindividual variability in drug responses. The S-mephenytoin 4′-hydroxylase CYP2C19 has become a subject of extensive studies concerning individual and ethnic variation of drug metabolism. Interethnic differences in drug metabolism may result from interethnical differences in distribution of a polymorphic trait and mutations which code for enzymes with abnormal activity which occur with altered frequency in different ethic groups. China is a multinationality country with 55 ethnic minorities besides the Han majority. The relatively unique genetic, cultural, dietetic and environmental characteristics of each of these nationalities should affect the catalytic activity of CYP2C19. Considering the high frequencies of defect in CYP2C19 in Chinese populations, the association of CYP2C19 with drug disposition and response should be particularly extended to more clinically used drugs in China.
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