Abstract
Background. Diabetic retinopathy (DR) is one of the most common consequences of diabetes. Retinopathy risk may be affected by genetic polymorphisms in the AKR1B1 gene. Method. One hundred thirty-four people with diabetes enrolled in the current study with 36 health control. An ophthalmological evaluation was done along with genotyping for the AKR1B1 rs9640883 SNP for all participants. Results. The result of genotyping the rs9640883 SNP in AKR1B1 with diabetic retinopathy is a GG pattern in all recruited cases with DR or cases without this complication (134 patients) and 36 controls. The mutant AA genotype and the heterozygote GA genotype were absent in the samples. Conclusion. rs9640883 polymorphism was absent in our samples of DR, and it suggests the presence of the wild type in this locus. The A allele of rs9640883 polymorphism was absent in our samples of DR, and it suggests the presence of the wild type (G allele) in this locus.
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