Abstract
e22058 Background: MicroRNAs (miRNA) may play important roles in tumorigenesis by regulating the expression of proto-oncogenes or tumor suppressor genes. Single nucleotide polymorphisms (SNPs) in miRNA-coding genes and miRNA binding site genes may affect miRNA-mediated gene regulation, thereby contributing to the susceptibility or prognosis of cancer. Accordingly, the present study analyzed SNPs located in miRNA and miRNA-binding sites of various genes and their impact on the prognosis for patients with early breast cancer by altering the miRNA binding efficiency. Methods: 452 consecutive patients with curative resection were enrolled. Three SNPs (rs11614913, rs3746444, and rs1044129 of miR-196a, miR-499a, and miR-367, respectively) were selected using an in silico analysis of several miRNA databases and the HapMap database. The SNP genotyping was performed using a Sequenom MassARRAY. Results: The median age of all the patients was 48 years, and 283 (62.6%) had ER/PR-positive EBC, 86 (19.0 %) had HER2-ove...
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