Abstract
BackgroundStroke is the second most common cause of death and major cause of disability worldwide. The SNP 83 in PDE4D gene has been suggested as a risk factor in ischemic stroke, but direct evidence from genetic association studies remains inconclusive even in Chinese population.MethodsMeta-analysis of case-control studies on the relationship between SNP 83 in PDE4D gene and susceptibility to ischemic stroke in Chinese population published domestically and abroad from January 2003 to September 2012.Results9 case-control studies were selected. Meta-analysis results showed that the significant association between SNP 83 and ischemic stroke was found under the dominant model (OR = 1.34, 95% CI: 1.20–1.49) and recessive model (OR = 1.45, 95% CI: 1.19–1.76) in Chinese population. In subgroup meta-analysis, SNP 83 and atherothrombotic stroke, rather than lacunar stroke, showed the significant association under the dominant model (OR = 1.69, 95% CI: 1.41–2.01) and recessive model (OR = 1.47, 95% CI: 1.04–2.06).ConclusionsThe results suggest that SNP 83 in PDE4D gene is significantly associated with susceptibility to ischemic stroke in Chinese population.
Highlights
Stroke is the second most common cause of death and major cause of disability worldwide. [1] In China, with 1.4 billion populations, the annual stroke mortality rate is approximately 1.6 million, which has exceeded heart disease to become the leading cause of death
In order to reduce heterogeneity from these confounding factors, we focus our attention on the association between SNP 83 in phosphodiesterase 4D (PDE4D) gene and ischemic stroke in Chinese population
A significant association between SNP 83 and ischemic stroke was found under the dominant model (OR = 1.34, 95% confidence interval (CI): 1.20–1.49, p,0.00001) and recessive model (OR = 1.45, 95% CI: 1.19–1.76, p = 0.0002), as shown in Figure 2 and 3
Summary
Stroke is the second most common cause of death and major cause of disability worldwide. [1] In China, with 1.4 billion populations, the annual stroke mortality rate is approximately 1.6 million, which has exceeded heart disease to become the leading cause of death. [1] In China, with 1.4 billion populations, the annual stroke mortality rate is approximately 1.6 million, which has exceeded heart disease to become the leading cause of death. [4] Genetic risk factors, suggested by evidence from twin, case-control and cohort studies of familial aggregation, might contribute to a predisposition to ischemic stroke. [6] In 2003, through genome-wide association study (GWAS), Gretarsdottir et al [7] identify the association of SNP 83 in PDE4D gene with carotid stroke in Icelandic population. In order to reduce heterogeneity from these confounding factors, we focus our attention on the association between SNP 83 in PDE4D gene and ischemic stroke in Chinese population. The SNP 83 in PDE4D gene has been suggested as a risk factor in ischemic stroke, but direct evidence from genetic association studies remains inconclusive even in Chinese population
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