Genetic Mosaics and Chimeras in Mammals

Abstract

Use of Chimeras and Cell Aggregations to Study Developmental Potency, Gene Expression, Control of Phenotype, and Tumor Origin.- Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice.- Viable chimeras produced from normal and parthenogenetic mouse embryos.- Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division.- Growth control in chimeras.- Attempts at locating the site of action of genes affecting behavior.- Fine structure of cells in embryos chimeric for mutant genes at the T/t locus.- An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells.- The use of mosaics and experimental chimeras to study the pathogenesis of neoplasia.- Antibodies to allozymes as potential cell markers for chimeric mouse studies.- Use of Chimeras and Mutational or Disjunctional Mosaics to Study Gamete Differentiation, Sexual Development, and Origin of the Germline.- Reproduction in single-sex chimeras.- Germ cells in XX ? XY mouse chimeras.- Use of the sex reversed gene (Sxr) to investigate functional sex reversal and gonadal determination in mammals.- Why not androgynes among mammals?.- Cell interactions in the sex organs of sex reversed mice heterozygous for testicular feminization.- Spontaneous sex mosaicism in BALB/cWt mice.- Evidence from mutable genes concerning the origin of the germ line.- X Chromosome Inactivation and Derepression.- Bimodal distribution of ?-galactosidase activities in mouse embryos.- Biochemical studies on X-chromosome activity in preimplantation mouse embryos.- Hypoxanthine guanine phosphoribosyl transferase expression in early mouse development.- The direct demonstration of an X-chromosome dosage effect prior to inactivation.- Use of teratocarcinoma stem cells as a model system for the study of X-chromosome inactivation in vitro.- The stability of X-chromosome inactivation: studies with mouse-human cell hybrids and mouse teratocarcinomas.- Studies of human-mouse cell hybrids with respect to X-chromosome inactivation.- X-Chromosome Nonrandomness: Imprinting, Selection.- Preferential inactivation of the paternally derived X chromosome in mice.- Preferential expression of the maternally derived X chromosome in extraembryonic tissues of the mouse.- In search of nonrandom X inactivation: studies of the placenta from newborns heterozygous for glucose-6-phosphate dehydrogenase.- The use of mouse X-autosome translocations in the study of X-inactivation pathways and nonrandomness.- Selection and cell communication as determinants of female phenotype.- Mathematical and Statistical Analyses of Mosaic Patterns.- Clonal growth versus cell mingling.- Combinatorial and computer analysis of random mosaics.- Data analysis of four X-chromosome inactivation experiments.