Abstract
Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics.
Highlights
Bronchial asthma is a chronic inflammatory disease of the respiratory tract, which involves a variety of cells and cellular components
With an understanding of the pathogenesis and the predisposing factors for asthma, and based on these asthma-susceptible genes, this paper focuses on finding potential asthma treatments, using a genetics-based drug repositioning method [6]
By studying the polymorphisms of the susceptible genes, we can explain the heterogeneity of diseases and determine the asthma severity [14], which will aid in developing an appropriate treatment corresponding to a patient’s unique asthma pathogenesis
Summary
Bronchial asthma is a chronic inflammatory disease of the respiratory tract, which involves a variety of cells and cellular components. Asthma affects people of all ages, but it often occurs during early childhood and is the most common childhood respiratory disease. Genetic variability among asthmatic patients and the effects of varied environmental factors has led to differences in asthma pathogenesis and the efficacy of treatment [2,5]. This has motivated the analysis of the genetic mechanisms, susceptibility genes, and environmental factors that are underlying asthma, in order to provide a reference for the clinical treatment of asthma. With an understanding of the pathogenesis and the predisposing factors for asthma, and based on these asthma-susceptible genes, this paper focuses on finding potential asthma treatments, using a genetics-based drug repositioning method [6]
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