Genetic markers of the metabolic syndrome in the Russian population (based on the ESSE-RF study)

Abstract

Objective. To assess the relationship of carriers of risk alleles for the rs9939609 polymorphisms of the FTO gene and rs1225537 of the TCF7L2 gene with the metabolic syndrome (MS) component in a national population sample of three regions (Samara, Orenburg, St Petersburg) as part of the ESSE-RF epidemiological study. Design and methods . The data of 3 regions were analyzed: Samara, Orenburg and St Petersburg. The total number of patients included in the study was 4 793 people, the average age of the examined was 45,6 ± 11,9 years. All participants in the study underwent an assessment of anthropometric parameters (height, weight, waist circumference), blood pressure and heart rate; serum glucose and lipids were measured, genotyping for the determination of single nucleotide polymorphism (SNP) rs1225537 of the TCF7L2 gene and rs9939609 of the FTO gene polymorphism was performed. Results. The occurrence and association of genotypes of the FTO and TCF7L2 gene with the components of MS were assessed separately in men and women. In women, the risk allele of the FTO gene was significantly more common among people with abdominal obesity. In males, the risk allele of the FTO gene was associated only with hyperglycemia. In both groups, the risk allele of the TCF7L2 gene was significantly more common in persons with hyperglycemia, while in men, the risk allele of the TCF7L2 gene was also associated with the development of abdominal obesity. Conclusions. We confirmed the association between the rs9939609 risk allele of the FTO gene with the development of abdominal obesity, as well as the risk allele rs1225537 of the TCF7L2 gene with the development of hyperglycemia in the Russian population. Our study also demonstrated various combinations of components of MS in the group of men and women in carriers of risk alleles s9939609 of the FTO gene and rs1225537 of the TCF7L2 gene.