Abstract
Chronic beryllium disease (CBD) is a pulmonary granulomatous hypersensitivity that is mediated by the proliferation liferation of CD4+ T cells. In vitro assays have shown that CD4+ T cells respond to beryllium salts in the context of class II molecules. An association between a specific motif on human leukocyte antigen (HLA)-DP (Glu-69) and beryllium hypersensitivity (BH) has been observed. Sequence specific oligonucleotide probes (SSOPs) were used to identify HLA-DRB1, -DRB3, -DRB4, and -DRB5 and HLA-DPB1 alleles in 29 persons with demonstrated BH and in individuals with beryllium exposure (BE) but no hypersensitivity.
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