Abstract
Adenine nucleotide translocases are mitochondrial membrane proteins encoded by a small dispersed multigene family. We have previously cloned cDNAs derived from the mouse adenine nucleotide translocase-1 and -2 genes (Ant1andAnt2) and assigned the loci to mouse chromosomes 8 and X, respectively. Here we describe the genomic organization of theAnt2gene and its regional map position on the X chromosome, which was determined through linkage analysis using an interspecific backcross betweenMus musculusandMus spretusinbred strains.Ant2cosegregates withDXMit49andDXMit50and lies distal toAgtr2in the proximal region of the mouse X chromosome. This map assignment further defines a region of conserved synteny between human Xq22–q25 and the mouse proximal X chromosome.
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