Abstract
Human tumor cell lines in culture show a wide range of radiosensitivity. Values for SF2 (surviving fraction at 2 Gy) typically range from 0.2 to 0.9 (data from our own laboratory). Radiotherapy employing 30–35 fractions of 2 Gy would therefore result in levels of cell kill that would mean certain failure for the most resistant tumors and certain cure for the most sensitive. Microenvironmental factors, such as hypoxia, also play an important role in determining outcome, but the problem of intrinsic radioresistance clearly needs to be addressed and attacked if radiotherapy is to be improved for the more resistant tumors. This will be true not only for resistant classes of tumors (e.g., melanomas) but also for individually resistant tumors within a curable class (e.g., head and neck tumors).
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