Abstract
Background and Aims : Aortic valve stenosis (AVS) is the most prevalent heart valve disease worldwide. Despite better interventional treatment strategies, AVS is associated with a high morbidity and mortality. The aortic valve is innervated, but the neural regulation of these AVS processes is unknown. Recently, a genome wide analysis study (GWAS) associated neuron navigator 1 (NAV1) with AVS. Since NAV1 is a microtubule-associated protein involved in developmental neural migration, the aim of the study was to establish the relation of NAV1 expression to AVS disease stages and AVS pathophysiological pathways, and to map the neural NAV1 to demonstrate its possible role in guiding the valvular anti-inflammatory cholinergic pathway.
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