Abstract
In an innovative scientific review in this issue, Grigoryev and colleagues report a method for choosing candidate genes for acute lung injury (ALI) based on gene expression data derived from multiple animal models of mechanical ventilation and shear stress. The authors conclude there are five key biologic processes that warrant further investigation: inflammatory and immune responses, cell proliferation, chemotaxis, and blood coagulation. This review represents an important first step toward studying the genetic epidemiology of ventilator-induced lung injury and ALI. The application of these findings to future human studies of the genetic influence on ALI risks and outcomes is discussed here.
Highlights
In recent years there has been growing interest in genetic susceptibility to acute lung injury (ALI) and in defining genetic determinants of outcomes in patients with established ALI [1,2]
In an innovative scientific review, those investigators report a method for choosing candidate genes for ALI based on gene expression data derived from multiple animal models of mechanical ventilation and shear stress
Generating key information for the investigation of ventilator-associated lung injury, the animal and cell models chosen to generate expression data in the review by Grigoryev and colleagues [3] may be limited in their generalizability to human ALI risk
Summary
In recent years there has been growing interest in genetic susceptibility to acute lung injury (ALI) and in defining genetic determinants of outcomes in patients with established ALI [1,2]. The study of genetic influence on ALI incidence and outcomes will involve gene association studies, such as case–control and cohort studies. Choosing the right genes to study is the first step in designing such research.
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