Abstract
Two recent articles in TiGS by Gerald Crabtree float the notion that we, as a species, are gradually declining in average intellect because we are accumulating mutations that deleteriously affect brain development or function [1,2]. The observations that prompted this view seem to be: (i) intellectual disability can be caused by mutations in any one of a very large number of genes; and (ii) de novo mutations arise at a low but steady rate in every new egg or sperm. He further proposes that (iii) genes involved in brain development or function are especially vulnerable to the effects of such mutations.
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