Abstract
Filamentous fungi are considered as unique cell factories for protein production due to the high efficiency of protein secretion and superior capability of post-translational modifications. In this review, we firstly introduce the secretory pathway in filamentous fungi. We next summarize the current state-of-the-art works regarding how various genetic engineering strategies are applied for enhancing protein expression and secretion in filamentous fungi. Finally, in a future perspective, we discuss the great potential of genome engineering for further improving protein expression and secretion in filamentous fungi.
Highlights
Protein production has a broad application in life sciences, biotechnology, medicine and material sciences
As for regulation of mycelium morphology and optimization of sterol regulatory element binding protein (SREBP), they were mainly adopted for production of endogenous protein, we believe that they are applicable for production of heterologous protein
Most efforts in genetic engineering of filamentous fungi for enhanced protein expression and secretion were solely based on the protein of interest, the secretory pathway or the host
Summary
Protein production has a broad application in life sciences, biotechnology, medicine and material sciences. Protein Production by Filamentous Fungi strategies based on genetic engineering of this particular cell factory to enhance protein expression and secretion.
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