Abstract
E. coli chromosomal DNA wastreated with various Pt co-ordiantion compounds and then used as donor DNA in E. coli transformation. Genetic analysis of transformants obtained with Pt-treated DNA showed effects of cis-diamminedichloroplatinum(II) ( cis-Pt(II)) and cis-dimethyl-1,3-diaminopropane CL 4 ( cis-Pt(IV) (DMDAP) on the processing of DNA. With trans-diamminedichloroplatinum(II) ( trans-Pt(II)) appllied in similar concentrations no effects were found. The effects of cis-Pt(II) and cis-Pt(IV) (DMDAP) on the genetic processing were different. The effects of cis-Pt(II) could be explained by assuming intra-strand crosslinks as an important lesion.
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