Abstract
In a recent analysis of nef gene sequences from a human immunodeficiency virus type 1 (HIV-1)-infected individual, Plikat et al. (5) conclude that genetic drift is the most important process of evolution in vivo. While we do not dispute the fact that stochastic processes may be important in shaping the genetic structure of HIV-1, we strongly reject the claim by Plikat et al. that their data can rule out immune-driven positive selection.
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