Abstract
Distribution of Toscana virus (TOSV) is evolving with climate change, and pathogenicity may be higher in nonexposed populations outside areas of current prevalence (Mediterranean Basin). To characterize genetic diversity of TOSV, we determined the coding sequences of isolates from Spain and France. TOSV is more diverse than other well-studied phleboviruses (e.g.,Rift Valley fever virus).
Highlights
Distribution of Toscana virus (TOSV) is evolving with climate change, and pathogenicity may be higher in nonexposed populations outside areas of current prevalence (Mediterranean Basin)
TOSV is widespread in the Mediterranean Basin, and evidence of human infection has been found in Italy, France, Spain, Portugal, Cyprus, and Turkey
We believe that obtaining genome sequence information for viruses with poor representation in public databases is an urgent task for the virologic community, especially for programs of virus surveillance and study of emerging pathogens
Summary
Ximena Collao,[1,2] Gustavo Palacios,[1] Sara Sanbonmatsu-Gámez, Mercedes Pérez-Ruiz, Ana I. The first patient was a 30-year-old man living in a rural area of Granada, Spain He had been admitted to hospital with headache, nausea, and fever; he was found to have meningeal and CSF pleocytosis. The wide variance of the TMRCA calculations might be affected by the scarce sequence information available, the differences observed might be related to their biological differences Both are phleboviruses transmitted by the bite of arthropods that could be implied as amplifier hosts; because TOSV is believed not to be amplified on its
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