Abstract
Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M- and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.
Highlights
Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri whitetoothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea
* Correspondence: jwsong@korea.ac.kr 1Department of Microbiology, College of Medicine, and Institute for Viral Diseases, Korea University, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Korea Full list of author information is available at the end of the article striped field mouse (Apodemus agrarius) populations near the demilitarized zone (DMZ) in Korea, provided an opportunity to investigate the genetic diversity and phylogeography of MJNV in the crocidurine shrew species reservoir
A total of 466 Ussuri white-toothed shrews were live caught in multiple sites, located 30 to 370 kilometers from Seoul, during March 2004 to May 2010 (Figure 1): Paju City, Yeoncheon-gun, Pocheon City, Dongducheon City, Yangpyeong-gun, Osan City, Suwon City and Pyeongtaek City in Gyeonggi province; Sincheorwongun and Pyeongchang-gun in Gangwon province; Gunsan City in Jeollabuk province; and Haenam-gun in Jeollanam province [10,11,12]
Summary
Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri whitetoothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. A novel hantavirus, named Imjin virus (MJNV), has been isolated from tissues of the Ussuri white-toothed shrew (Crocidura lasiura) captured in the Republic of Korea [7].
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