Genetic diversity of HLA system in two populations from Puebla, Mexico: Puebla city and rural Puebla

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2827 Mexicans from the state of Puebla living in the city of Puebla (N = 1994) and rural communities (N = 833), to obtain information regarding allelic and haplotypic frequencies. We found that the 16 most frequent haplotypes in Puebla are all of them Native American. Admixture estimates revealed that the main genetic components in the state of Puebla are Native American (72.21 ± 1.25% by ML; 63.30% of Native American haplotypes) and European (21.05 ± 1.92% by ML; 23.86% of European haplotypes), and a less prominent African genetic component (6.74 ± 2.20% by ML; 6.20% of African haplotypes).