Abstract
Mitochondria can produce the energy currency of the cell through respiration which would be affected by variation in mitochondrial DNA (mtDNA). We sequenced MT-ND3 and MT-ND4L genes in 51 Tibetan yaks, 59 Tibetan cattle, and 60 Holstein-Friesian. And the results showed that the SNPs (m.9893 A > G, m.9932 A > C, and m.10155 C > T) of MT-ND3 had negative associations with high-altitude adaptation (p < .003), while the SNP m.10073C > T was positively associated with high-altitude adaptation (p < .0006). Haplotypes H1 and H5 in MT-ND3 and Ha1 in MT-ND4L showed positive associations with high-altitude adaptability, while haplotype H3 and Ha3 negatively associated with this adaptability (p < .0014, p < .0017).
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