Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB1*15:01

Aya Kawasaki,Hiroshi Hashimoto,Isao Matsumoto,Kenji Itoh,Makio Kusaoi,Yuka Kawamura,Yuya Kondo,Takashi Fujimoto,Naoyuki Tsuchiya,Yasuyoshi Kusanagi,Naoto Tamura,Hirofumi Amano,Premita Ari Kusumawati,Takayuki Sumida

doi:10.1136/rmdopen-2023-003214

Genetic dissection of HLA-DRB115:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB115:01

Aya Kawasaki, Hiroshi Hashimoto + Show 12 more

Open Access

https://doi.org/10.1136/rmdopen-2023-003214

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Journal: RMD Open	Publication Date: May 1, 2023
Citations: 2	License type: open-access

Affiliation: Juntendo University, University of Tsukuba, National Defense Medical College, Nara Medical University, Juntendo University Nerima Hospital

#Systemic Lupus Erythematosus #TaqMan SNP Genotyping Assay + Show 8 more

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Abstract

ObjectiveMajor histocompatibility complex strongly contributes to susceptibility to systemic lupus erythematosus (SLE). In the European populations, HLA-DRB1*03:01 and DRB1*15:01 are susceptibility alleles, but C4 locus was reported to account for...

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