Abstract
Tobacco blue mold, caused by the obligately biotrophic oomycete pathogen Peronospora tabacina D.B. Adam, is a major foliar disease that results in significant losses in tobacco-growing areas. Natural resistance to P. tabacina has not been identified in any variety of common tobacco. Complete resistance, conferred by RBM1, was found in N. debneyi and was transferred into cultivated tobacco by crossing. In the present study, we characterized the RBM1-mediated resistance to blue mold in tobacco and show that the hypersensitive response (HR) plays an important role in the host defense reactions. Genetic mapping indicated that the disease resistance gene locus resides on chromosome 7. The genetic markers linked to this gene and the genetic map we generated will not only benefit tobacco breeders for variety improvement but will also facilitate the positional cloning of RBM1 for biologists.
Highlights
Common tobacco (Nicotiana tabacum L.) is one of the most important non-food crops worldwide, and is a model plant for biological research [1,2]
The diseased leaves became spotted with grey lesions that subsequently produced areas of abundant downy sporulation on the lower surface, while leaves of the resistant parent TKF 4321 remained healthy at the same time point (Supplementary Materials Figure S1)
Given the scarcity of genetic resources for resistance to blue mold in common tobacco, breeders introgressed blue mold resistance conferred by RBM1 from N. debneyi into tobacco to reduce the potential for losses from this disease
Summary
Common tobacco (Nicotiana tabacum L.) is one of the most important non-food crops worldwide, and is a model plant for biological research [1,2]. Known as water molds, are among the most devastating plant pathogens that cause notable diseases such as late blight of potato, downy mildew of grape vine, and root and stem rot of soybean. Tobacco blue mold, caused by the obligately biotrophic oomycete pathogen. P. hyoscyami de Bary), is a major foliar disease that causes significant crop losses in tobacco-growing areas around the world. Annual losses exceeding $200 million due to blue mold epidemics have been reported in the United States and Canada [5,6]
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