Abstract
The BALB/c mouse strain, derived from Bagg’s mice via Little, was properly inbred by MacDowell and later Snell, before the emergence of sublines (Staats, 1976). The C3H and other mouse strains developed by Strong, were not inbred enough before subline divergence started, so residual heterozygosity is a major problem and obscures subline differences due to genetic drift (Strong, 1978).
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