Abstract
Genetic factors have been shown to promote the development of pulmonary hypertension in both humans and animals. We previously described an inherent form of pulmonary hypertension in fawn-hooded rats (FHR), although the genetic basis for the pulmonary hypertension is unknown. Since the potent vasoconstrictor and mitogenic peptide endothelin-1 (ET-1) is overproduced from lungs and pulmonary artery smooth muscle cells of FHR, we tested whether genetic variation in genes of the endothelin family was the genetic basis for this form of pulmonary hypertension in the FHR by determining whether markers for these genes cosegregated with pulmonary hypertensive traits in crossbred rats.
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