Abstract
IntroductionThere is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease MethodsWe used a two-sample summary-statistics–based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk. ResultsOur results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk. DiscussionThis work encourages research on other modifiable biomarkers for Alzheimer's disease risk.
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