Abstract
BackgroundWith the legalization of cannabis in Canada, there is an increase trend in use. Cannabis has been known to have several health implications, one of which is the development of cannabis use disorder (CUD). CUD is more common in males than females, as well as in certain ethnic groups such as Native Americans. Additionally, both environmental and genetic risk factors have been found for cannabis use. The objective of this systematic review will be to summarize the genetic variants associated with cannabis use which have reached borderline genome-wide significance.MethodsThis systematic review will incorporate articles that have performed a genome-wide association study (GWAS) investigating cannabis use. MEDLINE, Web of Science, EMBASE, GWAS Catalog, GWAS Central, and NIH Database of Genotype and Phenotype will be searched using a comprehensive search strategy. The quality of genetic association studies (Q-Genie) tool will be utilized to assess the quality of the included studies. All screening and data extraction will occur independently by two authors. If feasible, a random-effects meta-analysis will be conducted on pooled odds ratios of single nucleotide polymorphisms reaching borderline genome-wide significance.DiscussionThis systematic review will synthesize available GWAS on cannabis use. Results from this review will inform and direct further investigation of genetic variants associated with cannabis use.Systematic review registrationPROSPERO CRD42020176016
Highlights
With the legalization of cannabis in Canada, there is an increase trend in use
Though genetic variants most commonly reported by genome-wide association study (GWAS) are single nucleotide polymorphisms (SNPs), this review will be inclusive of any other genetic markers reported in GWASs
A lack of consistent evidence exists in the current literature for genetic variants associated with cannabis use
Summary
With the legalization of cannabis in Canada, there is an increase trend in use. CUD is more common in males than females, as well as in certain ethnic groups such as Native Americans. Both environmental and genetic risk factors have been found for cannabis use. The objective of this systematic review will be to summarize the genetic variants associated with cannabis use which have reached borderline genome-wide significance. A genome-wide association study (GWAS) combined five cohorts identifying several genes and single nucleotide polymorphisms (SNPs) associated with cannabis use and dependence [5]. Of three meta-analyses conducted on cannabis use in the literature, only one study identified a significate association [6,7,8]. One region on chromosome 16 was significantly associated with age of first cannabis use, with the strongest association for the intronic variant rs1574587 [7]
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