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Abstract
Purpose: We recently found that Nuclear protein 1 (Nupr1), a stress-inducible transcription factor, is highly expressed in aged and osteoarthritic cartilage and in the knee joints of mice fed on high-fat diet. However, the role of Nupr1 in the development of OA is not clear. This study aimed to determine if genetic deletion of Nupr1 reduces the severity of cartilage lesions in surgically-induced osteoarthritis (OA) in mice
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