Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk.

Yuanyuan Zou,Xi Zhang,Jingyi Zhang,Shaozhen Zhao,Yuqing Liu,Xiangning Ji

doi:10.1590/1414-431x20198217

Abstract

The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done. Through the association test of overall meta-analysis, we did not observe a significant difference between RVO cases and controls under the A vs G (allele) (z=1.49, P=0.137), A vs G (carrier) (z=1.42, P =0.155), GA vs GG (z=1.50, P=0.135), and GA+AA vs GG (z=1.50, P=0.135). Furthermore, we observed similar negative results in the association test of subgroup analysis (all P>0.05). Heterogeneity, Begg's, and Egger's tests excluded the presence of high heterogeneity and publication bias. Statistically stable results were observed in the sensitivity analyses. Based on integrated analysis of the current evidence, Prothrombin gene G20210A polymorphism is likely unrelated to the risk of RVO.

Highlights

Retinal vein occlusion (RVO) is a common retinal vascular disease, and often contributes to the occurrence of visual decline or loss, especially for middle-aged or elderly individuals [1]
We conducted an updated meta-analysis and reported that ‘‘GA’’ genotype of Factor V G1691A polymorphism is associated with an increased susceptibility to RVO ( Central retinal vein occlusion (CRVO)) in a Caucasian population [2]
These findings suggested that G20210A polymorphism within Prothrombin gene had no role influencing the risk of central or branch retinal vein occlusion in the Caucasian population

Summary

Introduction

Retinal vein occlusion (RVO) is a common retinal vascular disease, and often contributes to the occurrence of visual decline or loss, especially for middle-aged or elderly individuals [1]. Central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) are two main types of RVO [1,2]. Genetic variants within a series of genes were reportedly associated with the risk of RVO [3]. Factor V G1691A (Factor V Leiden or R506Q) and G20210A polymorphism (rs1799963) within Prothrombin (Factor II) gene are the most common inherited thrombophilic mutations [4]. We conducted an updated meta-analysis and reported that ‘‘GA’’ genotype of Factor V G1691A polymorphism is associated with an increased susceptibility to RVO ( CRVO) in a Caucasian population [2]. We investigated the role of Prothrombin G20210A polymorphism in the risk of RVO.

Objectives

Results

Conclusion