Abstract
The discovery that inbred strains differ in their susceptibility to tumor-inducing (oncogenic) viruses (for a review, see Gross, 1970) triggered a search for genes specifically involved in the control of viral oncongenesis. It was hoped that identification of such genes would provide clues to the mechanism of the neoplastic process itself, but the search was only partially successful. The several genes that were implicated in the viral induction of tumors failed to reveal the mechanism of their involvement. The discovery by Lilly and his co-workers (1964) that viral leukemogenesis could be influenced by the H-2 system raised new hopes. Here the relationship between the gene and the neoplastic process seemed more apparent and more easily accessible to genetic analysis. Soon after this discovery, six other viruses were also demonstrated to be influenced by the H-2 system: Tennant virus, radiation-induced leukemia virus, Bittner virus, Friend virus, lymphocytic choriomeningitis virus, and vaccinia virus. Of these, the first five are RNA-containing viruses and the last is a DNA-containing virus. As the mechanism of action is probably different in each of the six, each will be described separately. A brief description of the properties of each virus will also be provided.
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