Abstract
SummaryHuman adult hemoglobin (Hb) was selected as a model oligomeric protein for investigations into Ir gene function. Separate genetic control of the α- and β-subunits of Hb was demonstrated. The relevant Ir genes were mapped to the I-A subregion and in particular to the Aβ gene for the α-chain of Hb. H-2b and H-2d mice are responders to the α-subunit and H-2d, H-2f and H-2s mice are responsive to the β-subunit. The subunits are not cross-reactive in T-cell assays. Non-H-2 linked genes are also important in Hb-specific immunity. There is a requirement for Ly-1+ T-cells for optimal responses in vitro.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
