Abstract
SummaryHuman adult hemoglobin (Hb) was selected as a model oligomeric protein for investigations into Ir gene function. Separate genetic control of the α- and β-subunits of Hb was demonstrated. The relevant Ir genes were mapped to the I-A subregion and in particular to the Aβ gene for the α-chain of Hb. H-2b and H-2d mice are responders to the α-subunit and H-2d, H-2f and H-2s mice are responsive to the β-subunit. The subunits are not cross-reactive in T-cell assays. Non-H-2 linked genes are also important in Hb-specific immunity. There is a requirement for Ly-1+ T-cells for optimal responses in vitro.
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