Abstract
Monoclonal anti-Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I-A gene control of immunity to human haemoglobin (Hb). It was found that the A beta gene is of critical importance in conferring immunity to the alpha-chain and beta-chain subunits of Hb. A possible involvement of I-E region genes in B10.D2 mice to beta-chain is discussed. Through the use of an alpha-chain specific T cell clone data, is obtained indicating that an intact Ia.8+ A beta chain is necessary for antigen presentation in vitro.
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