Abstract
Some groups of psychiatric patients differ from normal individuals with respect to mean platelet monoamine oxidase (MAO) activity. Twin studies indicate that genetic factors contribute to the considerable interindividual variability in the activity of this enzyme. To evaluate the degree of genetic control, we measured platelet MAO activity in 255 normal adult members of 112 families. Between-family variance was significantly greater than within-family variance, as would be expected. Parent-offspring and sibling-sibling correlations indicated that genetic factors control platelet MAO activity to a substantial extent.
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