Abstract
It is well established that small bowel transplants can induce graft-vs-host (GVH) reactions which are potentially lethal for the graft recipients. Using a model of MHC congenic and recombinant rat strains, we have characterized the genetic control of GVH reactions after parental to F1 hybrid small bowel transplantation. Lethal graft-vs-host disease (GVHD) in the rat is primarily mediated by class II MHC incompatibility, while class I MHC and non-MHC antigens do not induce a symptomatic GVH reactivity. Following small bowel transplantation, not only may GVH reactions occur, but the transplant is also a potential victim of rejection. In our rat model, we have now analyzed the genetic control of host-vs-graft (HVG) reactions after F1 hybrid to parental small bowel transplantation and compared the results after heterotopic and orthotopic placement.
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