Abstract
A small proportion of the peripheral lymphocytes responds to a first exposure to transplantation antigens. The number of responsive cells varies 3− to 5-fold among inbred and hybrid lines of White Leghorn chickens, and this variation is independent of the total numbers of lymphocytes and leukocytes. The lowest numbers were found in lines homozygous for blood group allele B2 and the highest numbers were found in lines homozygous for B14, both of which are principal determinants of specific histoincompatibility. The number of effective cells in the F1 and F2B heterozygotes is the geometric mean of the numbers present in the parental and F2 homozygotes. The exactness with which the B heterozygotes fit the geometric mean is interpreted to mean that the number of mitoses which occur during the differentiation of responsive cells, prior to their first contact with antigen, is associated in some way with the B locus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
