Abstract
Mice of the inbred strain BALB/cJ, which have a greater number of midbrain dopamine neurons, have more dopaminergic receptors of the DA 2 class in the caudate nucleus but exhibit a greater cataleptic response to neuroleptic drugs than mice of the CBA/J strain. Variations in the number of dopaminergic receptors may be genetically determined and influence the magnitude of behaviors produced by drugs which are active on brain dopaminergic systems.
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