Abstract
AbstractThe manufacture of mammalian chimeras by aggregating embryos of different genetic constitutions makes possible the study of the genetic control of cellular interactions during embryonic development. Several different chimeric combinations have been made to study the role of the sex‐reversed mutation in gonadogenesis and in gametogenesis. Sex reversed directs the gonad to become a testis and thus renders a SxrXX mouse sterile since gonocytes with two X chromosomes cannot complete gametogenesis in a testis. However, SxrXX gonocytes in the ovary of a female chimera become normal oocytes. The competitive interactions of genetically different melanoblasts in populating hair follicles and of primordial germ cells in populating the gonad have been revealed in chimeras. Chimeras have also been used to rescue inviable teraploid embryos and to permit teteraploid cells to display their differentiative capacities in normal tissue environments. We conclude that the genotype affects the capacity of cells to elaborate and to respond to inductive stimuli at each step in differentiation. The fine tuning of cellular interactions becomes apparent in chimeras made from embryos of different genotype.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
