Abstract
Lung carcinogenesis is strongly influenced byenvironmental and heritable factors. The genetic contribution to the different histologic subtypes is unknown. A population-based computerized genealogy resource linked to a statewide cancer registry of lung cancer cases (N= 5408) was analyzed to evaluate the heritable contribution to lung cancer histologic subtype in smokers (n= 1751) and nonsmokers (n= 818). Statistical methods were used to test for significant excess relatedness of lung cancer cases. Significant excess distant relatedness was observed for all lung cancer histologic subgroups analyzed except for the SCLC subset (p= 0.213). When histologic subsets of smokers and nonsmokers with lung cancer were considered, excess relatedness was observed only in nonsmokers with NSCLC (n= 653 [p= 0.026]) and, in particular, in those nonsmokers with the nonsquamous histologic subtype (n= 561 [p= 0.036]). A total of 61 pedigrees demonstrating a significant excess risk of nonsquamous lung cancer in nonsmokers were identified, and an excess of cases in females was observedamong the individuals with these high-risk pedigrees. This analysis supports a genetic predisposition to lung cancer carcinogenesis in nonsmokers with nonsquamous NSCLC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
