Abstract
Femoral neck geometry parameters are believed to be as good as bone mineral density as independent factors in predicting hip fracture risk. This study was conducted to analyze the roles of genetic and environmental factors in femoral properties measured in a sample of Spanish families with osteoporotic fractures and extended genealogy. The “Genetic Analysis of Osteoporosis (GAO) Project” involved 11 extended families with a total number of 376 individuals. We studied three categorical phenotypes of particular clinical interest and we used a Hip structural analysis based on DXA to analyze 17 strength and geometrical phenotypes of the hip. All the femoral properties had highly significant heritability, ranging from 0.252 to 0.586. The most significant correlations were observed at the genetic level (ρG). Osteoporotic fracture status (Affected 2) and, particularly, low bone mass and osteoporotic condition (Affected 3) had the highest number of significant genetic correlations with diverse femoral properties. In conclusion, our findings suggest that a relatively simple and easy to use method based on DXA studies can provide useful data on properties of the Hip in clinical practice. Furthermore, our results provide a strong motivation for further studies in order to improve the understanding of the pathophysiological mechanism underlying bone architecture and the genetics of osteoporosis.
Highlights
Hip fracture is recognized as the most serious osteoporotic fracture due to its association with increased morbidity and mortality, and decreased functional capacity with a one-year mortality of approximately 20% [1, 2]
We aim to analyze the relative importance of genetic and environmental factors in Femoral neck geometry parameters (FNGPs) measured by means of dual X-ray absorptiometry (DXA)-based hip structural analysis (HSA) in a set of extended Spanish families characterized by osteoporotic fractures
The patients included in the analysis are from the Genetic Analysis of Osteoporosis (GAO) Project
Summary
Hip fracture is recognized as the most serious osteoporotic fracture due to its association with increased morbidity and mortality, and decreased functional capacity with a one-year mortality of approximately 20% [1, 2]. It is important to quantify the assorted genetic and environmental factors that may contribute to osteoporotic fractures in order to help to prevent hip fracture in particular. Genetic of Femoral Neck Geometry and Osteoporosis
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