Genetic Clustering Algorithm-Based Feature Selection and Divergent Random Forest for Multiclass Cancer Classification Using Gene Expression Data

Abstract

AbstractComputational identification and classification of clinical disorders gather major importance due to the effective improvement of machine learning methodologies. Cancer identification and classification are essential clinical areas to address, where accurate classification for multiple types of cancer is still in a progressive stage. In this article, we propose a multiclass cancer classification model that categorizes the five different types of cancers using gene expression data. To perform efficient analysis of the available clinical data, we propose feature selection and classification methods. We propose a genetic clustering algorithm (GCA) for optimal feature selection from the RNA-gene expression data, consisting of 801 samples belonging to the five major classes of cancer. The proposed feature selection method reduces the 1621 gene expressions into a cluster of 21 features. The optimum feature set acts as input data to the proposed divergent random forest. Based on the features computed, the proposed classifier categorizes the data samples into 5 different classes of cancers, including breast cancer, colon cancer, kidney cancer, lung cancer, and prostate cancer. The proposed divergent random forest provided performance improvisation in terms of accuracy with 95.21%, specificity with 93%, and sensitivity with 94.29% which outperformed all the other existing multiclass classification algorithms.